Project title

The Effect of Hyperoxaemia on Platelet Function During ECMO


Dr Rylan Hayes, Associate Professor Kiran Shekar,
Professor John Fraser


Extracorporeal membrane oxygenation (ECMO) is an expanding modality of organ support in severe cardiorespiratory dysfunction. Unfortunately numerous complications remain prevalent during ECMO. There exists an ongoing need to identify factors contributing to complications so that outcomes may be improved. Platelet function is one factor known to be altered during ECMO by multiple mechanisms, however, whether the unique exposure to hyperoxaemia during ECMO contributes to this dysfunction is currently unclear.

Research Plan

The investigation is being undertaken in sequential phases to investigate platelet function during ECMO and the effect that hyperoxaemia imparts. The study design involves progression from in vivo ovine models to ex vivo ECMO circuits using human blood. Finally, in vivo human studies in the form of retrospective and prospective analyses will add clinical correlation to the findings of the project


Hayes R, Foley S, Shekar K et al: Ovine platelet function is unaffected by extracorporeal membrane oxygenation within the first 24 h. Blood Coagul Fibrinolysis 2015

Hayes R, Shekar K, Fraser J: Hyperoxic damage and the need for optimised oxygenation practices. Critical Care 2013, 17:441.

Hayes R, Shekar K, Fraser J: Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem. Perfusion 2013, 28:184–93.