There is a significant body of work that has emerged in last 5 years to guide antimicrobial dosing on ECMO. The article discusses whether antimicrobial dosing, based on principles of drug dosing during critical illness, along with therapeutic drug monitoring will suffice during ECMO.
Ki KK, Passmore MR, Chan CHH, Malfertheiner MV, Fanning JP, Bouquet M, Millar JE, Fraser JF, Suen JY. Intensive Care Med Exp. 2019 Aug 20;7(1):51.
The use of Extracorporeal membrane oxygenation (ECMO) is on the rise, however there are still significant complications including bleeding and thrombosis. In the following study led by Post Doc Katrina Ki, the CCRG team has shown that high vs low flow rates in ECMO differentially alter a number of haemostatic parameters.
Shekar K, Brodie D. Crit Care Med. 2019 Aug;47(8):1147-1149.
ECMO support enables clinicians to rest the diseased native lungs while they heal and recover. However optimal mechanical ventilation strategy on ECMO is not tested in clinical studies. While protecting lungs from iatrogenic harm during mechanical ventilation is important, this article argues that excessive lung testing may actually be detrimental to the patient.
Schmidt M, Combes A, Shekar K. Intensive Care Med. 2019 Aug;45(8):1140-1142.
Patient selection is key for the success of ECMO therapy. There is a growing population of immunosuppressed patients globally. Respiratory failure is a leading cause of death in these patients and this article explores the risk:benefits of applying ECMO in the immunosuppressed
See Hoe LE, Bartnikowski N, Wells MA, Suen JY, Fraser JF. Int J Mol Sci. 2019 Aug 5;20(15).