Hemorrhage, Disseminated Intravascular Coagulopathy, and Thrombosis Complications Among Critically Ill Patients with COVID-19

Fanning, Jonathon P., Weaver, Natasha, Fanning, Robert B., Griffee, Matthew J., Cho Sung-Min, Panigada, Mauro, Obonyo, Nchafatso G. Zaaqoq, Akram M.; Rando, Hannah; Chia, Yew Woon; Fan, Bingwen Eugene; Sela, Declan; Chiumello, Davide; Coppola, Silvia; Labib, Ahmed; Whitman, Glenn J. R.; Arora, Rakesh C.; Kim, Bo S.; Motos, Anna; Torres, Antoni; Barbé, Ferran; Grasselli, Giacomo; Zanella, Alberto; Etchill, Eric; Usman, Asad Ali MMD, MPH30; Feth, Maximilian; White, Nicole M.; Suen, Jacky Y.; Li Bassi, Gianluigi; Peek, Giles J.; Fraser, John F.; Dalton, Heidi on behalf of the COVID-19 Critical Care Consortium (COVID Critical) Critical Care Medicine DOI: 10.1097/CCM.0000000000005798

Measurements and Main Results: HECTOR complications occurred in 1,732 of 11,969 study eligible patients (14%). Acute thrombosis occurred in 1,249 patients (10%), including 712 (57%) with pulmonary embolism, 413 (33%) with myocardial ischemia, 93 (7.4%) with deep vein thrombosis, and 49 (3.9%) with ischemic strokes. Hemorrhagic complications were reported in 579 patients (4.8%), including 276 (48%) with gastrointestinal hemorrhage, 83 (14%) with hemorrhagic stroke, 77 (13%) with pulmonary hemorrhage, and 68 (12%) with hemorrhage associated with extracorporeal membrane oxygenation (ECMO) cannula site. Disseminated intravascular coagulation occurred in 11 patients (0.09%).

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A novel speckle-tracking echocardiographic parameter considering left ventricular loading condition in cardiogenic shock during VA ECMO

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A Comprehensive Evaluation of Hemodynamic Energy Production and Circuit Loss using Four Different ECMO Arterial Cannulae