The efficacy of telavancin in comparison with linezolid on endotracheal tube biofilm in pigs with methicillin-resistant Staphylococcus aureus pneumonia

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Kasra Kiarostami, Laia Fernández-Barat, Denise Battaglini, Anna Motos, Leticia Bueno-Freire, Alba Soler-Comas, Gianluigi Li Bassi, Antoni Torres DOI 10.1016/j.ijantimicag.2023.107052

Background The effect of systemic treatment of ventilator-associated pneumonia (VAP) with telavancin, a semisynthetic lipoglycopeptide with good penetration in vitro biofilms, has not been tested in vivo during mechanical ventilation. This study examined the efficacy of telavancin compared with linezolid against endotracheal tube (ETT) biofilms in a porcine model of methicillin-resistant Staphylococcus aureus (MRSA) VAP.

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