The Impact of Acute Exercise on Hemostasis and Angiogenesis Mediators in Patients With Continuous-Flow Left Ventricular Assist Devices

Chan, C., Passmore, M., Tronstad, O., Seale, H., Bouquet, M., White, N., Teruya, J., Hogan, A., Platts, D., Chan, W., Dashwood, A., McGiffin, D., Maiorana, A., Hayward, C., Simmonds, M., Tansley, G., Suen, J., Fraser, J., Meyns, B., Fresiello, L., Jacobs, S. ASAIO Journal DOI: 10.1097/MAT.0000000000002246

Abstract: Impaired primary hemostasis and dysregulated angiogenesis, known as a two-hit hypothesis, are associated with gastrointestinal (GI) bleeding in patients with continuous-flow left ventricular assist devices (CF-LVADs). Exercise is known to influence hemostasis and angiogenesis in healthy individuals; however, little is known about the effect in patients with CF-LVADs. The objective of this prospective observational study was to determine whether acute exercise modulates two-hit hypothesis mediators associated with GI bleeding in patients with a CF-LVAD.