Resuscitation-associated endotheliopathy (RAsE)

A conceptual framework based on a systematic review and meta-analysis

Nchafatso G. Obonyo, Declan P. Sela, Sainath Raman, Reema Rachakonda, Bailey Schneider, Louise E. See Hoe, Jonathon P. Fanning, Gianluigi Li Bassi, Kathryn Maitland, Jacky Y. Suen & John F. Fraser Syst Rev. DOI 10.1186/s13643-023-02385-0

Introduction: Shock-induced endotheliopathy (SHINE), defined as a profound sympathoadrenal hyperactivation in shock states leading to endothelial activation, glycocalyx damage, and eventual compromise of end-organ perfusion, was first described in 2017. The aggressive resuscitation therapies utilised in treating shock states could potentially lead to further worsening endothelial activation and end-organ dysfunction.

Objective: This study aimed to systematically review the literature on resuscitation-associated and resuscitation-induced endotheliopathy.