Corticosteroid and antimicrobial therapy in macrolide-resistant pneumococcal pneumonia porcine model

Motos, A., Yang, M., Battaglini, D., Yang, H., Meli, A., Bobi, J., Cabrera, R., Tanzella, G., Vargas, C. R., Arrieta, M., Llonch, B., Rovira-Ribalta, N., Barbeta, E., di Giannatale, P., Nogas, S., Fernández-Barat, L., Rigol, M., Kiarostami, K., Martín-Loeches, I., Vila, J., Martinez, D., Li Bassi, G., & Torres, A. Intensive Care Medicine Experimental DOI: 10.1186/s40635-025-00731-1

Abstract: Streptococcus pneumoniae, a primary cause of community-acquired pneumonia (CAP), is typically treated with β-lactams and macrolides or quinolones. Corticosteroids are now recommended as adjunctive therapy in severe CAP to improve outcomes. In this prospective randomized animal study, we evaluated the bactericidal efficacy of various antibiotic regimens combined with corticosteroids using a porcine pneumococcal pneumonia model.