A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era

31 May

Written By CCRG

Nchafatso G Obonyo, Peter Olupot-Olupot, Ayub Mpoya, Julius Nteziyaremye, Martin Chebet, Sophie Uyoga, Rita Muhindo, Jonathon P Fanning, Kenji Shiino, Jonathan Chan, John F Fraser, Kathryn Maitland. DOI: 10.1097/PCC.0000000000002968

Objectives: Fluid bolus resuscitation in African children is harmful. Little research has evaluated physiologic effects of maintenance-only fluid strategy.

Design: We describe the efficacy of fluid-conservative resuscitation of septic shock using case-fatality, hemodynamic, and myocardial function endpoints.

Setting: Pediatric wards of Mbale Regional Referral Hospital, Uganda, and Kilifi County Hospital, Kenya, conducted between October 2013 and July 2015. Data were analysed from August 2016 to July 2019.

Patients: Children (≥ 60 d to ≤ 12 yr) with severe febrile illness and clinical signs of impaired perfusion.

sepsis

CCRG

A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era

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