A new frontier for an old drug? …

Maybauer, M. O. and D. M. Maybauer (2015). "A new frontier for an old drug? A word of caution for beta-blockers in sepsis!" Current Medical Research and Opinion 31(10): 1829-1830.

Recent promising findings indicate a possible benefit of beta-blockade in septic patients. Ongoing trials on esmolol in septic shock are investigating its hemodynamic effects, focusing on heart rate control and echocardiographic changes, as well as potential anti-inflammatory effects. However, given the complex physiology of sepsis and pharmacological effects on beta-blockade, large multi-center trials are essential before such a therapy may be applied safely.