Anti-Fouling Surfaces for Extracorporeal Membrane Oxygenation by Surface Grafting of Hydrophilic Sulfoxide Polymers

2022
Written By CCRG CCRG Admin

Yuhao Zhang, Meili Zhang, Xin Xu, Chris H. H. Chan, Hui Peng, David J. T. Hill, Changkui Fu, John Fraser, and Andrew K. Whittaker. Biomacromolecules

DOI 10.1021/acs.biomac.2c00775

Abstract: Non-thrombogenic surfaces for extracorporeal membrane oxygenation (ECMO) devices are important to increase their duration of usage and to enable long-term life support. However, the contact of blood with the hydrophobic synthetic ECMO membrane materials such as poly(4-methyl-1-pentene) (PMP) can activate the coagulation cascade, causing thrombosis and a series of consequent complications during ECMO operation. Targeting this problem, we proposed to graft highly hydrophilic sulfoxide polymer brushes onto the PMP surfaces via gamma ray irradiation-initiated polymerization to improve the hemocompatibility of the membrane.

CCRG CCRG Admin
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