Bilateral Femoral Cannulation is associated with reduced Severe Limb Ischemia-related complications compared with Unilateral Femoral Cannulation in Adult Peripheral Venoarterial ECMO

Results From the Extracorporeal Life Support Registry

Simons J, Di Mauro M, Mariani S, Ravaux J, van der Horst ICC, Driessen RGH, Sels JW, Delnoij T, Brodie D, Abrams D, Mueller T, Taccone FS, Belliato M, Broman ML, Malfertheiner MV, Boeken U, Fraser J, Wiedemann D, Belohlavek J, Barrett NA, Tonna JE, Pappalardo F, Barbaro RP, Ramanathan K, MacLaren G, van Mook WNKA, Mees B, Lorusso R. Crit Care Med. DOI: 10.1097/CCM.0000000000006040

Objectives: Peripheral venoarterial extracorporeal membrane oxygenation (ECMO) with femoral access is obtained through unilateral or bilateral groin cannulation. Whether one cannulation strategy is associated with a lower risk for limb ischemia remains unknown. We aim to assess if one strategy is preferable.

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Human neutrophil antigen 3 genotype impacts neutrophil-mediated endothelial cell cytotoxicity in a two-event model of TRALI