Donor heart ischemic time can be extended beyond 9 hours using hypothermic machine perfusion in sheep

2023
Written By CCRG CCRG Admin

See Hoe LE, Li Bassi G, Wildi K, Passmore MR, Bouquet M, Sato K, Heinsar S, Ainola C, Bartnikowski N, Wilson ES, Hyslop K, Skeggs K, Obonyo NG, Shuker T, Bradbury L, Palmieri C, Engkilde-Pedersen S, McDonald C, Colombo SM, Wells MA, Reid JD, O'Neill H, Livingstone S, Abbate G, Haymet A, Jung JS, Sato N, James L, He T, White N, Redd MA, Millar JE, Malfertheiner MV, Molenaar P, Platts D, Chan J, Suen JY, McGiffin DC, Fraser JF. J. Heart Lung Transplant. DOI 10.1016/j.healun.2023.03.020

Abstract: The global shortage of donor hearts available for transplantation is a major problem for the treatment of end-stage heart failure. The ischemic time for donor hearts using traditional preservation by standard static cold storage (SCS) is limited to approximately 4 hours, beyond which the risk for primary graft dysfunction (PGD) significantly increases. Hypothermic machine perfusion (HMP) of donor hearts has been proposed to safely extend ischemic time without increasing the risk of PGD.

CCRG CCRG Admin
Previous

Bilateral femoral cannulation ss associated with reduced severe limb ischemia-related complications compared to unilateral femoral cannulation in adult peripheral V-A ECMO
Next

Relationship between grip strength during hospitalisation and mental disorders after discharge in critically ill patients