Effect of caffeine on adenosine-induced …

Lee, J. C., et al. (2012). "Effect of caffeine on adenosine-induced reversible perfusion defects assessed by automated analysis." Journal of Nuclear Cardiology 19(3): 474-481.

This prospective study investigated the effects of caffeine ingestion on the extent of adenosine-induced perfusion abnormalities during myocardial perfusion imaging (MPI). Thirty patients with inducible perfusion abnormalities on standard (caffeine-abstinent) adenosine MPI underwent repeat testing with supplementary coffee intake. Baseline and test MPIs were assessed for stress percent defect, rest percent defect, and percent defect reversibility. Plasma levels of caffeine and metabolites were assessed on both occasions and correlated with MPI findings. Despite significant increases in caffeine [mean difference 3,106 mu g/L (95% CI 2,460 to 3,752 mu g/L; P < .001)] and metabolite concentrations over a wide range, there was no statistically significant change in stress percent defect and percent defect reversibility between the baseline and test scans. The increase in caffeine concentration between the baseline and the test phases did not affect percent defect reversibility (average change -0.003 for every 100 mu g/L increase; 95% CI -0.17 to 0.16; P = .97). There was no significant relationship between the extent of adenosine-induced coronary flow heterogeneity and the serum concentration of caffeine or its principal metabolites. Hence, the stringent requirements for prolonged abstinence from caffeine before adenosine MPI-based on limited studies-appear ill-founded.