Extracorporeal Membrane Oxygenation-Induced Hemolysis: An In Vitro Study to Appraise Causative Factors

Chan CHH, Ki KK, Zhang M, Asnicar C, Cho HJ, Ainola C, Bouquet M, Heinsar S, Pauls JP, Li Bassi G, Suen J, Fraser JF. Membranes DOI 10.3390/membranes11050313

Abstract: In vitro hemolysis testing is commonly used to determine hemocompatibility of ExtraCorporeal Membrane Oxygenation (ECMO). However, poor reproducibility remains a challenging problem, due to several unidentified influencing factors. The present study investigated potential factors, such as flow rates, the use of anticoagulants, and gender of blood donors, which could play a role in hemolysis.