Hyperoxia during venoarterial ECMO: Culprit or co-variate? A comment from the BLENDER investigators

Premraj L, Brown A, Burrell A, Fraser JF, & Pilcher D Critical Care DOI 10.1186/s13054-022-04213-8

Abstract: The clinical significance of hyperoxia in critically ill patients remains unclear. Oxidative stress has been linked to the progression of numerous disease states. It can be defined as an imbalance between the production of reactive oxygen species (ROS) and anti-oxidant capacity resulting in damage of cellular components. Exposure to supraphysiological partial pressures of oxygen can induce oxidative stress. Interpretation of observational studies and clinical trials is exceedingly challenging due to heterogeneity brought about by patient and disease factors.