Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving ECMO and RRT using dosing software

Roberts J.A, Bellomo R, Cotta M.O, Koch B.C.P, Lyster H, Ostermann M, Roger C, Shekar K, Watt K, Abdul-Aziz M.H. Intensive Care Med. 2022 48:10 (1338-1351) DOI: 10.1007/s00134-022-06847-2

Abstract: Intensive care unit (ICU) patients with end-organ failure will require specialised machines or extracorporeal therapies to support the failing organs that would otherwise lead to death. ICU patients with severe acute kidney injury may require renal replacement therapy (RRT) to remove fluid and wastes from the body, and patients with severe cardiorespiratory failure will require extracorporeal membrane oxygenation (ECMO) to maintain adequate oxygen delivery whilst the underlying pathology is evaluated and managed.