Ovine red cell concentrates for transfusion research - is the storage lesion comparable to human red cell concentrates?

Simonova, G., Wellburn, R., Fung, Y. L., Fraser, J. F., & Tung, J. P. (2021). Ovine red cell concentrates for transfusion research - is the storage lesion comparable to human red cell concentrates?. Vox sanguinis, 116(5), 524–532. https://doi.org/10.1111/vox.13020

Background and objectives: Sheep are increasingly being used as a large in vivo animal model of blood transfusion because they provide several advantages over small animals. Understanding the effects of storage duration on ovine (ov) red cell concentrates (RCCs) and how these changes compare with stored human (hu) RCCs is necessary to facilitate clinical translation of research findings.