Performance of the ESC 0/2h-algorithm using high-sensitivity cardiac troponin I in the early diagnosis of myocardial infarction

Koechlin, L., Boeddinghaus, J., Nestelberger, T., Lopez-Ayala, P., Wussler, D., Shrestha, S., Resa, T., Wildi, K., Bakula, A., Frey, S., Miró, Ò., Martin-Sanchez, F. J., Strebel, I., Gualandro, D. M., Eckstein, F. S., Reuthebuch, O., Keller, D. I., Twerenbold, R., Giménez, M. R., Mueller, C., … APACE investigators (2021). https://doi.org/10.1016/j.ahj.2021.08.008

The 2020 guidelines of the European Society of Cardiology (ESC) recommend a novel ESC 0/2h-algorithm as the preferred alternative to the ESC 0/1h-algorithm in the early triage for rule-out and/or rule-in of Non-ST-segment-elevation myocardial infarction (NSTEMI). The aim was to prospectively validate the performance of the ESC 0/2h-algorithm using the high-sensitivity cardiac troponin I (hs-cTnI) assay (ARCHITECT) in an international, multicenter diagnostic study enrolling patients presenting with acute chest discomfort to the emergency department.