Population Pharmacokinetics and Dosing Simulations of Ceftriaxone in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation

Cheng, V, Abdul-Aziz, M. H, Burrows, F, Buscher, H, Cho, Y. J, Corley, A, Gilder, E, Kim, H. S, Lim, S. Y, McGuinness, S, Parke, R, Reynolds, C, Rudham, S, Wallis, S. C, Welch, S. A, Fraser, J. F, Shekar, K, Roberts, J. A, & ASAP ECMO Investigators. Clin Pharmacokinet. DOI: 10.1007/s40262-021-01106-x

Background: Despite the surge in use of extracorporeal membrane oxygenation (ECMO) in the adult intensive care unit, little guidance is available on the appropriate dosing of antimicrobials in this setting. Ceftriaxone is an antimicrobial with a high affinity to plasma protein, a property identified in the literature as susceptible to sequestration into extracorporeal circuits and hypothesised to require dosage adjustments in this setting.