Preclinical Studies on Pulsatile Veno-Arterial Extracorporeal Membrane Oxygenation: A Systematic Review
Kanagarajan, Dhayananth; Heinsar, Silver; Gandini, Lucia; Suen, Jacky Y; Dau Van Thanh; Pauls, Jo; and Fraser, John F. ASAIO Journal DOI: 10.1097/MAT.0000000000001922
Abstract: Refractory cardiogenic shock is increasingly being treated with veno-arterial extracorporeal membrane oxygenation (V-A ECMO), without definitive proof of improved clinical outcomes. Recently, pulsatile V-A ECMO has been developed to address some of the shortcomings of contemporary continuous-flow devices. To describe current pulsatile V-A ECMO studies, we conducted a systematic review of all preclinical studies in this area. We adhered to PRISMA and Cochrane guidelines for conducting systematic reviews.