In vivo evaluation of skin integration with ventricular assist device drivelines

2022
Written By CCRG CCRG Admin

Cavalcanti AS, Diaz RS, Bolle ECL, Bartnikowski N, Fraser JF, McGiffin D, Savi FM, Shafiee A, Dargaville TR, Gregory SD. J Heart Lung Transplant. DOI: 10.1016/j.healun.2022.03.014

Background: Ventricular assist device (VAD) driveline exit site infection is a common complication. 3D scaffolds manufactured with highly homogeneous pores via melt electro-writing (MEW) may generate an improved skin-driveline interface which permits cellular in-growth and creates a barrier to prevent bacterial migration along the driveline tissue tunnel. This study investigated skin integration on segments of Heartmate 3 driveline: smooth polyurethane, velour, and on a custom MEW scaffold in a small animal model.

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