Short-Term Effects of Appropriate Empirical Antimicrobial Treatment with Ceftolozane/Tazobactam in a Swine Model of Nosocomial Pneumonia

Motos, A., Li Bassi, G., Pagliara, F., Fernandez-Barat, L., Yang, H., Aguilera Xiol, E., Senussi, T., Idone, F. A., Travierso, C., Chiurazzi, C., Amaro, R., Yang, M., Bobi, J., Rigol, M., Nicolau, D. P., Frigola, G., Cabrera, R., Ramirez, J., Pelosi, P., Blasi, F., … Torres, A. (2021). Short-Term Effects of Appropriate Empirical Antimicrobial Treatment with Ceftolozane/Tazobactam in a Swine Model of Nosocomial Pneumonia. Antimicrobial agents and chemotherapy, 65(2), e01899-20. https://doi.org/10.1128/AAC.01899-20

Abstract: The rising frequency of multidrug-resistant and extensively drug-resistant (MDR/XDR) pathogens is making more frequent the inappropriate empirical antimicrobial therapy (IEAT) in nosocomial pneumonia, which is associated with increased mortality. We aim to determine the short-term benefits of appropriate empirical antimicrobial treatment (AEAT) with ceftolozane/tazobactam (C/T) compared with IEAT with piperacillin/tazobactam (TZP) in MDR Pseudomonas aeruginosa pneumonia.