ARISE FLUIDS: A multi-centre observational study describing current practice in Australia and New Zealand

Keijzers, G., Macdonald, S. P., Udy, A. A., Arendts, G., Bailey, M., Bellomo, R., Blecher, G. E., Burcham, J., Coggins, A. R., Delaney, A., Fatovich, D. M., Fraser, J. F., Harley, A., Jones, P., Kinnear, F. B., May, K., Peake, S., Taylor, D. M., Williams, P., & the ARISE FLUIDS Observational Study Group (2020). The Australasian Resuscitation In Sepsis Evaluation: Fluids or vasopressors in emergency department sepsis (ARISE FLUIDS), a multi-centre observational study describing current practice in Australia and New Zealand. Emergency medicine Australasia : EMA, 32(4), 586–598. https://doi.org/10.1111/1742-6723.13469

Objectives: To describe haemodynamic resuscitation practices in ED patients with suspected sepsis and hypotension.

Methods: This was a prospective, multicentre, observational study conducted in 70 hospitals in Australia and New Zealand between September 2018 and January 2019. Consecutive adults presenting to the ED during a 30-day period at each site, with suspected sepsis and hypotension (systolic blood pressure <100 mmHg) despite at least 1000 mL fluid resuscitation, were eligible. Data included baseline demographics, clinical and laboratory variables and intravenous fluid volume administered, vasopressor administration at baseline and 6- and 24-h post-enrolment, time to antimicrobial administration, intensive care admission, organ support and in-hospital mortality.