Association between driving pressure, systemic inflammation and non-pulmonary organ dysfunction in patients with acute respiratory distress syndrome

Written By CCRG

Barbeta, E., Ferrando, C., López-Aladid, R., Motos, A., Bueno-Freire, L., Fernández-Barat, L., Soler-Comas, A., Palomeque, A., Gabarrús, A., Artigas, A., Camprubí-Rimblas, M., Li Bassi, G., López-Sobrino, T., Sandoval, E., Toapanta, D., Fernández, S., Mellado-Artigas, R., Zattera, L., Vallverdú, J., Laffey, J. G., Ferrer, M., Torres, A. Anaesthesia, Critical Care & Pain Medicine DOI: 10.1016/j.accpm.2024.101458

Abstract: Driving pressure is thought to determine the effect of low tidal ventilation on survival in patients with acute respiratory distress syndrome. The leading cause of mortality in these patients is non-pulmonary multiorgan dysfunction, which is believed to worsen due to the biological response to mechanical ventilation (biotrauma). Therefore, we aimed to analyze the association between driving pressure, biotrauma, and non-pulmonary multiorgan dysfunction. Additionally, we analyzed this relationship for tidal volume/predicted body weight.

CCRG
Previous

Management of severe acute respiratory distress syndrome in Australia and New Zealand (SAGE-ANZ)
Next

Extended perioperative use of the ProtekDuo cannula for drainage in central venopulmonary-aortic ECMO forbilateral orthotopic lung transplantation