Effects of transfusing older red blood cells on patient outcomes in critical illness

Obonyo, N. G., Sela, D. P., White, N., Tunbridge, M., Sim, B., Rachakonda, R. H., See Hoe, L. E., Li Bassi, G., Fanning, J. P., Tung, J.-P., Suen, J. Y., & Fraser, J. F. Vox Sanguinis DOI: 10.1111/vox.70007

Abstract: Randomized controlled trials have demonstrated morbidity and mortality in critically ill patients are unaffected by transfusing fresh (<7 days old) packed red blood cells (pRBCs); however, there is limited evidence regarding transfusion with pRBCs nearing expiry (35–42 days). The aim of this study was to investigate the effects of transfusing pRBCs close to the end of shelf life (≥35 days) on clinical outcomes in critically ill patients.

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