In Silico Analysis of Pulsatile Flow Veno-Arterial Extracorporeal Membrane Oxygenation on Human Aorta Model

Dhayananth Kanagarajan, Silver Heinsar, Van Thanh Dau, Jo P Pauls, Geoffrey D Tansley, John F Fraser. ASAIO Journal DOI: 10.1097/MAT.0000000000002418

Abstract: Electrocardiogram (ECG)-synchronized pulsatile veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is a recent development in extracorporeal therapy for patients with severe cardiogenic shock. Although preclinical studies have shown benefits of pulsatile flow relative to continuous ECMO flow, none have explored the effects of the timing of ECMO pulses with respect to the cardiac cycle and its possible implications on ECMO complications.