Application of anti-inflammatory treatment in two different ovine Acute Respiratory Distress Syndrome injury models

Written By CCRG

A preclinical randomized intervention study

Karin Wildi, Samantha Livingstone, Carmen Ainola, Sebastiano Maria Colombo, Silver Heinsar, Noriko Sato, Kei Sato, Mahé Bouquet, Emily Wilson, Gabriella Abbate, Margaret Passmore, Kieran Hyslop, Keibun Liu, Xiaomeng Wang, Chiara Palmieri, Louise E. See Hoe, Jae-Seung Jung, Katrina Ki, Christian Mueller, John Laffey, Paolo Pelosi, Gianluigi Li Bassi, Jacky Suen & John Fraser Sci Rep DOI 10.1038/s41598-023-45081-8

Abstract: Whilst the presence of 2 subphenotypes among the heterogenous Acute Respiratory Distress Syndrome (ARDS) population is becoming clinically accepted, subphenotype-specific treatment efficacy has yet to be prospectively tested. We investigated anti-inflammatory treatment in different ARDS models in sheep, previously shown similarities to human ARDS subphenotypes, in a preclinical, randomized, blinded study.

CCRG
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