Hypothermic oxygenated perfusion (HOPE) safely and effectively extends acceptable donor heart preservation times - results of the Australian and New Zealand trial

Written By CCRG

David C. McGiffin, Christina E. Kure, Peter S. Macdonald, Paul C. Jansz, Sam Emmanuel, Silvana F. Marasco, Atsuo Doi, Chris Merry, Robert Larbalestier, Amit Shah, Agneta Geldenhuys, Amul K. Sibal, Cara A. Wasywich, Jacob Mathew, Eldho Paul, Caitlin Cheshire, Angeline Leet, James L. Hare, Sandra Graham, John F. Fraser, David M. Kaye J Heart Lung Transplant DOI 10.1016/j.healun.2023.10.020

Background: Cold static storage preservation of donor hearts for periods longer than 4 hours increases the risk of primary graft dysfunction (PGD). The aim of the study was to determine if hypothermic oxygenated perfusion (HOPE) could safely prolong the preservation time of donor hearts.

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