Brain stem death induces pro-inflammatory cytokine production and cardiac dysfunction in sheep model

Walweel, K., Boon, A. C., See Hoe, L. E., Obonyo, N. G., Pedersen, S. E., Diab, S. D., Passmore, M. R., Hyslop, K., Colombo, S. M., Bartnikowski, N. J., Bouquet, M., Wells, M. A., Black, D. M., Pimenta, L. P., Stevenson, A. K., Bisht, K., Skeggs, K., Marshall, L., Prabhu, A., James, L. N., … Fraser, J. F. (2021). https://doi.org/10.1016/j.bj.2021.10.007

Abstract: Organs procured following brain stem death (BSD) are the main source of organ grafts for transplantation. However, BSD is associated with inflammatory responses that may damage the organ and affect both the quantity and quality of organs available for transplant. Therefore, we aimed to investigate plasma and bronchoalveolar lavage (BAL) pro-inflammatory cytokine profiles and cardiovascular physiology in a clinically relevant 6-hour ovine model of BSD.

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Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes

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Nutrition therapy in the intensive care unit during the COVID-19 pandemic: Findings from the ISIIC point prevalence study