Coagulation Dysfunction in Acute Respiratory Distress Syndrome and Its Potential Impact in Inflammatory Subphenotypes

Samantha A. Livingstone, Karin S. Wildi1, Heidi J. Dalton, Asad Usman, Katrina K. Ki, Margaret R. Passmore, Gianluigi Li Bassi, Jacky Y. Suen, and John F Fraser. Front. Med.     DOI: 10.3389/fmed.2021.723217

Abstract: Acute Respiratory Distress Syndrome (ARDS) is a critical respiratory syndrome plagued by severe hypoxaemia and loss of pulmonary function. Five decades after it was first described ARDS still represents over 10% of all Intensive Care Unit (ICU) admissions and is the cause of almost one quarter of patients requiring mechanical ventilation. It is also responsible for hundreds of thousands of deaths worldwide annually.